Package: mbbe
Title: Model Based Bio-Equivalence
Version: 0.1.0
Authors@R: 
    c(person(given = "Mark", 
           family = "Sale", 
           email = "mark.sale@certara.com", 
           role = c("aut", "cre"),
           comment = c(ORCID = "0000-0002-6239-2359",
                      "Funded by FDA/NIH grant 1U01FD007355")),
      person(given = "James", 
           family = "Craig", 
           email = "james.craig@certara.com", 
           role = c("aut"),
           comment = c(ORCID = "0000-0003-1757-9234")
           ),
      person(given = "Michael", 
           family = "Tomashevskiy", 
           email = "michael.tomashevskiy@certara.com", 
           role = c("aut") 
           )
           )
Description: Uses several Nonlinear Mixed effect (NONMEM) models (as NONMEM control files)
    to perform bootstrap model averaging and Monte Carlo Simulation for Model Based 
    Bio-Equivalence (MBBE). Power is returned as the fraction of the simulations with 
    successful bioequivalence (BE) test, for maximum concentration (Cmax), Area under the 
    curve to the last observed value (AUClast) and Area under the curve extrapolate to 
    infinity (AUCinf). See Hooker, A. (2020) Improved bioequivalence assessment through 
    model-informed and model-based strategies <https://www.fda.gov/media/138035/download>.
URL: https://github.com/certara/mbbe
BugReports: https://github.com/certara/mbbe/issues
License: LGPL-3
Encoding: UTF-8
Imports: dplyr, stringr, xml2, PKNCA, magrittr, nlme, emmeans, future,
        furrr (>= 0.3.1), processx, tictoc, ggplot2, ps, jsonlite
RoxygenNote: 7.2.3
Suggests: knitr, rmarkdown, testthat
VignetteBuilder: knitr
NeedsCompilation: no
Packaged: 2024-02-01 14:38:04 UTC; jcraig
Author: Mark Sale [aut, cre] (<https://orcid.org/0000-0002-6239-2359>, Funded
    by FDA/NIH grant 1U01FD007355),
  James Craig [aut] (<https://orcid.org/0000-0003-1757-9234>),
  Michael Tomashevskiy [aut]
Maintainer: Mark Sale <mark.sale@certara.com>
Repository: CRAN
Date/Publication: 2024-02-03 11:20:02 UTC
Built: R 4.2.3; ; 2024-02-03 15:01:34 UTC; unix
